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Pulmonary Immunotoxicity of Inhaled Ammonium Metavanadate in Fisher 344 Rats.
- Source :
- Fundamental & Applied Toxicology; 1996, Vol. 33 Issue 2, p254-263, 10p
- Publication Year :
- 1996
-
Abstract
- Male Fisher 344 rats were exposed to 2 mg vanadium(V)/m3 (as ammonium metavanadate NH4VO3, 0.32 μm MMD) atmospheres for 8 hr/day for 4 days in a nose-only exposure system. In exposed rats, lung V burdens increased in a time-dependent fashion. Analysis of lung cells and lavage fluid 24 hr after the final exposure suggested that tissue damage and a strong inflammatory response was elicited; numbers of neutrophil and small macrophages (Mø), as well as levels of lavageable protein and lactate dehydrogenase, were significantly elevated as compared with levels observed with air-exposed rats. Vanadium also affected pulmonary alveolar Mø (PAM) capacities to produce and respond to immunoregulating cytokines. Inducible PAM production of tumor necrosis factor-a was significantly inhibited, as was the ability to increase cell surface Class II/I-A molecule expression in response to interferon-γ (rFN-γ). PAM from V-exposed hosts were also inhibited in their ability to be primed by EFN-γ to produce superoride anion and hydrogen peroxide in response to stimulation with opsonized zy-mosan. These studies indicate that short-term repeated exposure of rats to atmospheric V, at levels encountered in an occupational setting, can alter host pulmonary immunomocompetence, with one major effect occurring at the level of cytokine-related functions. These alterations may be underlying mechanisms for the well-documented increases in bronchopulmonary infections and cancers in workers chronically exposed to V-containing atmospheres. [ABSTRACT FROM AUTHOR]
- Subjects :
- RATS
VANADIUM
AMMONIUM
NEUTROPHILS
MACROPHAGES
PULMONARY alveoli
CYTOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 02720590
- Volume :
- 33
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Fundamental & Applied Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 82415642
- Full Text :
- https://doi.org/10.1093/toxsci/33.2.254