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Diagnostic performance of fluorine-18-dihydroxyphenylalanine positron emission tomography in diagnosing and localizing the focal form of congenital hyperinsulinism: a meta-analysis.
- Source :
- Pediatric Radiology; Nov2012, Vol. 42 Issue 11, p1372-1379, 8p, 1 Diagram, 4 Charts, 5 Graphs
- Publication Year :
- 2012
-
Abstract
- Introduction: We performed a meta-analysis on published data on the diagnostic performance of fluorine-18 dihydroxyphenylalanine (F-DOPA) positron emission tomography (PET) in diagnosing and localizing focal congenital hyperinsulinism (CHI). Materials and methods: A comprehensive computer literature search of studies published up to 31 January 2012 regarding F-DOPA PET or PET/CT in patients with CHI was performed. Pooled sensitivity and specificity, area under the ROC curve and diagnostic odds ratio (DOR) of F-DOPA PET or PET/CT in diagnosing focal CHI were calculated. The localization accuracy of focal CHI was also estimated. Seven studies comprising 195 CHI patients were included. Results: The pooled sensitivity and specificity of F-DOPA PET or PET/CT in differentiating between focal and diffuse CHI were 89% (95% confidence interval [CI]:81-95%) and 98% (95% CI:89-100%), respectively. The DOR was 74.5 (95% CI:18-307). The area under the ROC curve was 0.95. The pooled accuracy of these functional imaging methods in localizing focal CHI was 80% (95% CI:71-88%). Discussion: In CHI patients, F-DOPA PET or PET/CT demonstrated high sensitivity and specificity in differentiating between focal and diffuse CHI. F-DOPA PET or PET/CT are accurate methods of localizing focal CHI. Nevertheless, possible sources of false-negative results for focal CHI should be kept in mind. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03010449
- Volume :
- 42
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Pediatric Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 82763635
- Full Text :
- https://doi.org/10.1007/s00247-012-2459-2