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Synchronous versus asynchronous oscillations for antigenically varying Plasmodium falciparum with host immune response.
- Source :
- Journal of Biological Dynamics; Mar2012, Vol. 6 Issue 2, p333-357, 25p
- Publication Year :
- 2012
-
Abstract
- We consider a deterministic intra-host model for Plasmodium falciparum (Pf) malaria infection, which accounts for antigenic variation between n clonal variants of PfEMP1 and the corresponding host immune response (IR). Specifically, the model separates the IR into two components, specific and cross-reactive, respectively, in order to demonstrate that the latter can be a mechanism for the sequential appearance of variants observed in actual Pf infections. We show that a strong variant-specific IR relative to the cross-reactive IR favours the asynchronous oscillations (sequential dominance) over the synchronous oscillations in a number of ways. The decay rate of asynchronous oscillations is smaller than that for the synchronous oscillations, allowing for the parasite to survive longer. With the introduction of a delay in the stimulation of the IR, we show that only a small delay is necessary to cause persistent asynchronous oscillations and that a strong variant-specific IR increases the amplitude of the asynchronous oscillations. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 17513758
- Volume :
- 6
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Biological Dynamics
- Publication Type :
- Academic Journal
- Accession number :
- 82935377
- Full Text :
- https://doi.org/10.1080/17513758.2011.582169