Study of the pragmatic of saliva test cassette to detect the Helicobacter pylori in oral cavity.

Objective To study the link of Helicobacter pylori salive test cassette (HPS) and ¹³C-urea breath test (¹³C-UBT) on detecting Helicobacter pylon infection of stomach, and the sensitivity as well as specificity should be determined. Methods A screening trial of ¹³C-UBT and HPS tests was carried out 130 patients included 106 positive and 24 negative results of ¹³C-UBT. As gold standards of ¹³C-UBT, a comparison study with HPS was evaluated using Bayes formula. Results The sensitivity, specificity, accuracy, positive and negative predictive value of HPS was 68.87%, 58.33%, 66.92%, 87.95%, 29.79% respectively. The coincidence was 66.92%. Conclusion There is a correlation between results of ¹³C-UBT and HPS. Combination of ¹³C-UBT and HPS may compensate the blind zone of ¹³C-UBT in detecting oral Helicobacter pylon infection. ¹³C-UBT could not be used as a gold standard to judge the validation of HPS in detecting Helicobacter pylon oral infection. The methods can be used at the same time in clinic. [ABSTRACT FROM AUTHOR]