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Overexpression of BMI-1 is associated with poor prognosis in cervical cancer.
- Source :
- Asia Pacific Journal of Clinical Oncology; Dec2012, Vol. 8 Issue 4, pe55-e62, 8p
- Publication Year :
- 2012
-
Abstract
- Aim It has been reported that BMI-1, a gene transcription promoter overexpressed in various human cancers, is associated with poor survival. We investigated whether BMI-1 is a marker for cervical cancer by detecting the expression of BMI-1 in cervical cancer. Methods An immunohistochemistry (IHC) streptavidin-peroxidase technique was used to identify BMI-1 protein expression in 302 cervical cancer specimens. Reverse transcription polymerase chain reaction and Western blot were employed to measure BMI-1 mRNA and protein level. The correlation between BMI-1 expression and clinicopathological factors was analyzed. Results Both BMI-1 mRNA and protein expression were evident in cervical carcinoma tissues. An intense positive rate of 55.3% (167/302) was observed by IHC. High BMI-1 expression was correlated with clinical stage, lymph node metastasis, vascular invasion and human papillomavirus (HPV) infection ( P < 0.05), but there is insufficient evidence to confirm its value in tumor size, age, estrogen or progesterone receptor ( P > 0.05). The BMI-1 protein level was positively correlated with the clinical stages of cervical carcinoma and a high BMI-1 expression was associated with poor prognosis ( P < 0.05). Conclusion The high expression of BMI-1 in cervical cancer is related to tumor progression, lymph node metastasis and HPV infection, suggesting that cervical cancer with excessive BMI-1 expression possesses high metastases potential and that BMI-1 may be a promising biomarker for predicting metastasis in cervical cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17437555
- Volume :
- 8
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Asia Pacific Journal of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 83632982
- Full Text :
- https://doi.org/10.1111/j.1743-7563.2012.01564.x