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Diastereomeric Resolution of Racemic o-Chloromandelic Acid.
- Source :
- Chirality; Dec2012, Vol. 24 Issue 12, p1013-1017, 5p
- Publication Year :
- 2012
-
Abstract
- ABSTRACT The separation of rac-o-chloromandelic acid 1 with enantiopure aryloxypropylamine via diastereomeric salt formation was investigated. ( R)- o-chloromandelic acid ( R)- 1, a key intermediate for the antithrombotic agent clopidogrel, was obtained in 65% yield and 98% ee by Dutch resolution of rac- 1 with ( S)-2-hydroxyl-3-( p-chlorophenoxy) propylamine ( S)- 5 as resolving agent and ( S)-2-hydroxyl-3-( o-nitrophenoxy) propylamine ( S)- 4 as nucleation inhibitor. Chirality 24:1013-1017, 2012. © 2012 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08990042
- Volume :
- 24
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Chirality
- Publication Type :
- Academic Journal
- Accession number :
- 83711566
- Full Text :
- https://doi.org/10.1002/chir.22089