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Association of Type 2 Diabetes Susceptibility Variants With Advanced Prostate Cancer Risk in the Breast and Prostate Cancer Cohort Consortium.
- Source :
- American Journal of Epidemiology; Dec2012, Vol. 176 Issue 12, p1121-1129, 9p
- Publication Year :
- 2012
-
Abstract
- Observational studies have found an inverse association between type 2 diabetes (T2D) and prostate cancer (PCa), and genome-wide association studies have found common variants near 3 loci associated with both diseases. The authors examined whether a genetic background that favors T2D is associated with risk of advanced PCa. Data from the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium, a genome-wide association study of 2,782 advanced PCa cases and 4,458 controls, were used to evaluate whether individual single nucleotide polymorphisms or aggregations of these 36 T2D susceptibility loci are associated with PCa. Ten T2D markers near 9 loci (NOTCH2, ADCY5, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, MTNRIB, FTO, and HNFIB) were nominally associated with PCa (P< 0.05); the association for single nucleotide polymorphism rs757210 at the HNFIB locus was significant when multiple comparisons were accounted for (adjusted P= 0.001). Genetic risk scores weighted by the T2D log odds ratio and multilocus kernel tests also indicated a significant relation between T2D variants and PCa risk. A mediation analysis of 9,065 PCa cases and 9,526 controls failed to produce evidence that diabetes mediates the association of the HNF1B locus with PCa risk. These data suggest a shared genetic component between T2D and PCa and add to the evidence for an interrelation between these diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 2 diabetes risk factors
PROSTATE tumors
CONFIDENCE intervals
STATISTICAL correlation
DATABASES
DISEASE susceptibility
EPIDEMIOLOGY
GENETIC polymorphisms
MEDICAL information storage & retrieval systems
RESEARCH funding
GENETIC markers
LOGISTIC regression analysis
GENOMICS
DATA analysis
CONTROL groups
GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 176
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 84585931
- Full Text :
- https://doi.org/10.1093/aje/kws191