Back to Search
Start Over
Intakes of long-chain omega-3 (n-3) PUFAs and fish in relation to incidence of asthma among American young adults: the CARDIA study.
- Source :
- American Journal of Clinical Nutrition; Jan2013, Vol. 97 Issue 1, p173-178, 6p, 2 Charts
- Publication Year :
- 2013
-
Abstract
- Background: Although long-chain ω-3 (n-3) PUFAs (LCco3PUFAs) have been linked to the prevention of some inflammatory disorders, little is known about the association between these fatty acids and incidence of asthma. Objective: The objective was to prospectively investigate the association between LCω3PUFAs and fish intake and incidence of asthma among American young adults. Design: A 20-y follow-up longitudinal analysis was conducted in a biracial cohort of 4162 Americans, aged 18-30 y, with a history of asthma at baseline in 1985. Diet was assessed by a validated interviewer-administered quantitative food-frequency questionnaire at the examinations in 1985, 1992, and 2005. Incident self-reported asthma was defined as having a physician diagnosis of asthma and/ or the use of asthma medications between 1985 and 2005. Results: During the 20-y follow-up, 446 incident cases of asthma were identified. LCco3PUFA intake was significantly inversely associated with incidence of asthma after adjustment for sociodemo- graphic, major lifestyle, and dietary confounders. The multivariable- adjusted HR for the highest quintile of LCω3PUFA intake as compared with the lowest quintile was 0.46 (95% CI: 0.33, 0.64; P-trend < 0.01). However, a higher frequency of nonfiied fish con- sumption was not significantly associated with the risk of asthma. DHA showed a greater inverse association than did EPA. The associ- ation between LCβ3PUFAs and incident asthma was not appreciably modified by sex, race, BMI, smoking status, or atopic status. Conclusion: This study showed that intakes of LCβ3PUFAs are inversely longitudinally associated with the incidence of asthma in American young adults. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLAMMATION
FATTY acids
ASTHMA
BODY mass index
LIFESTYLES
DIET research
DIET
FISHES
ANALYSIS of variance
CHI-squared test
CONFIDENCE intervals
EPIDEMIOLOGY
FAT content of food
INTERVIEWING
LONGITUDINAL method
MEDICAL cooperation
NUTRITIONAL assessment
OMEGA-3 fatty acids
QUESTIONNAIRES
RESEARCH
RESEARCH evaluation
RESEARCH funding
SELF-evaluation
STATISTICS
DATA analysis
PROPORTIONAL hazards models
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 97
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 84606716
- Full Text :
- https://doi.org/10.3945/ajcn.112.041145