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Impact of UGT1A1 Gilbert Variant on Discontinuation of Ritonavir-Boosted Atazanavir in AIDS Clinical Trials Group Study A5202.
- Source :
- Journal of Infectious Diseases; Feb2013, Vol. 207 Issue 3, p420-425, 6p
- Publication Year :
- 2013
-
Abstract
- The UGT1A1*28 variant has been associated with hyperbilirubinemia and atazanavir discontinuation. Protocol A5202 randomly assigned human immunodeficiency virus type 1 (HIV-1)–infected patients to receive atazanavir/ritonavir (atazanavir/r) or efavirenz, with tenofovir/emtricitabine or abacavir/lamivudine. A total of 646 atazanavir/r recipients were evaluable for UGT1A1. Homozygosity for *28/*28 was present in 8% of whites, 24% of blacks, and 18% of Hispanics and was associated with increased bilirubin concentrations. There was an association between *28/*28 and increased atazanavir/r discontinuation among Hispanic participants (P = .005) but not among white or black participants (P = .79 and P = .46, respectively). The positive predictive value of 28*/28* for atazanavir/r discontinuation among Hispanic participants was only 32% (95% confidence interval, 16%–52%). [ABSTRACT FROM PUBLISHER]
- Subjects :
- HYPERBILIRUBINEMIA
ATAZANAVIR
HIV
BILIRUBIN
EMTRICITABINE
RITONAVIR
LAMIVUDINE
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 207
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 84670506
- Full Text :
- https://doi.org/10.1093/infdis/jis690