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Synthesis of Novel Amide Derivatives with In Vitro Antiproliferative and Cytotoxic Activity.
- Source :
- Heteroatom Chemistry; 2013, Vol. 24 Issue 1, p9-17, 9p
- Publication Year :
- 2013
-
Abstract
- ABSTRACT Some amide derivatives are highly valuable products with antiproliferative and cytotoxic bioactivity. In this paper, 12 novel amide compounds were synthesized correspondingly by boc-protection glycine, deprotection, and condensation reactions. The antiproliferative and cytotoxic activity of these compounds was also evaluated by human cervical cancer (Hela) and hepatoma carcinoma (SK-Hep-1) cancer cell lines. The assay revealed that eight compounds ( 5a-d, 6a-d) exhibited activity against Hela cancer cells. Four of them ( 5a-d) also showed activity against SK-Hep-1 cancer cells. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 24:9-17, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21057 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10427163
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Heteroatom Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 84677271
- Full Text :
- https://doi.org/10.1002/hc.21057