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Characteristics of Plasmacytoid Dendritic Cell and CD4+ T Cell in HIV Elite Controllers.
- Source :
- Clinical & Developmental Immunology; 2012, p1-8, 8p, 1 Chart, 1 Graph
- Publication Year :
- 2012
-
Abstract
- Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load andmassive CD4+ T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains an undetectable viral load. This infrequent patient population is defined as HIV-1 controllers (HIV controllers), and represents less than 1% of HIV-1-infected patients. HIV-1-specific CD4+ T cells and the pool of central memory CD4+ T cells are also preserved despite immune activation due to HIV-1 infection. The majority of HIV controllers are also defined by the absence of massive CD4+ T-cell depletion, even after 10 years of infection. However, the mechanisms involved in protection against HIV-1 disease progression have not been elucidated yet. Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV-positive persons
AIDS
DENDRITIC cells
CD4 antigen
T cells
IMMUNE response
Subjects
Details
- Language :
- English
- ISSN :
- 17402522
- Database :
- Complementary Index
- Journal :
- Clinical & Developmental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 84745562
- Full Text :
- https://doi.org/10.1155/2012/869505