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Mathematical modeling of the immune system recognition to mammary carcinoma antigen.
- Source :
- BMC Bioinformatics; 2012, Vol. 13 Issue Suppl 17, p1-15, 15p, 1 Diagram, 2 Charts, 9 Graphs
- Publication Year :
- 2012
-
Abstract
- The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNITY
VACCINATION
CANCER
ANTIGENS
T cells
Subjects
Details
- Language :
- English
- ISSN :
- 14712105
- Volume :
- 13
- Issue :
- Suppl 17
- Database :
- Complementary Index
- Journal :
- BMC Bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 84780441
- Full Text :
- https://doi.org/10.1186/1471-2105-13-S17-S21