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Pharmacokinetic Comparison of Ferulic Acid in Normal and Blood Deficiency Rats after Oral Administration of Angelica sinensis, Ligusticum chuanxiong and Their Combination.

Authors :
Weixia Li
Jianming Guo
Yuping Tang
Huan Wang
Meiyan Huang
Dawei Qian
Jin-Ao Duan
Source :
International Journal of Molecular Sciences; Mar2012, Vol. 13 Issue 3, p3583-3597, 15p
Publication Year :
2012

Abstract

Radix Angelica Sinensis (RAS) and Rhizome Ligusticum (RLC) combination is a popular herb pair commonly used in clinics for treatment of blood deficiency syndrome in China. The aim of this study is to compare the pharmacokinetic properties of ferulic acid (FA), a main bioactive constituent in both RAS and RLC, between normal and blood deficiency syndrome animals, and to investigate the influence of compatibility of RAS and RLC on the pharmacokinetic of FA. The blood deficiency rats were induced by injecting 2% Acetyl phenylhydrazine (APH) on the first day, every other day, to a total of five times, at the dosage of 100, 50, 50, 30, 30 mg/kg body mass, respectively. Quantification of FA in rat plasma was achieved by using a simple and rapid HPLC method. Plasma samples were collected at different time points to construct pharmacokinetic profiles by plotting drug concentration versus time, and estimate pharmacokinetic parameters. Between normal and blood deficiency model groups, both AUC<subscript>(0-t)</subscript> and C<subscript>max</subscript> of FA in blood deficiency rats after RAS-RLC extract administration increased significantly (P < 0.05), while clearance (CL) decreased significantly. Among three blood deficiency model groups, t<subscript>1/2</subscript>α, V<subscript>d</subscript>, AUC<subscript>(0-t)</subscript> and AUC<subscript>(0-∞)</subscript> all increased significantly in the RAS-RLC extract group compared with the RAS group. The results indicated that FA was absorbed better and eliminated slower in blood deficiency rats; RLC could significantly prolong the half-life of distribution, increase the volume of distribution and the absorption amount of FA of RAS in blood deficiency rats, which may be due to the synergic action when RAS and RLC were used together to treat blood deficiency syndrome. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
13
Issue :
3
Database :
Complementary Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
85001948
Full Text :
https://doi.org/10.3390/ijms13033583