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Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia.
- Source :
- British Journal of Haematology; Dec2002, Vol. 119 Issue 3, p769-772, 4p
- Publication Year :
- 2002
-
Abstract
- Summary. Three patients with myelofibrosis received allogeneic stem cell transplantation after a dose-reduced conditioning regimen of busulphan (8 mg/kg), fludarabine (180 mg/m<superscript>2</superscript> ) and antithymocyte globulin (4 × 10 mg/kg). The median age at transplantation was 51 years (range 44–58). All patients engrafted with a leucocyte count > 1·0 × 10<superscript>9</superscript> /l after a median of 18 d (range 16–20). Grade II acute skin graft-versus-host disease (GvHD) occurred in one patient. One limited and one extensive chronic GvHD was observed. All patients achieved complete haematological remission. In one patient the fibrosis resolved completely 180 d post transplant. All patients are alive 126, 466 and 764 d after transplantation. [ABSTRACT FROM AUTHOR]
- Subjects :
- MYELOFIBROSIS
STEM cell transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 119
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 8514992
- Full Text :
- https://doi.org/10.1046/j.1365-2141.2002.03884.x