Somatic mutations of PHF6 in patients with chronic myeloid leukemia in blast crisis.

The article discusses research which investigated plant homeodomain (PHD)-like finger protein 6 (PHF6) gene mutations in patients with chronic myeloid leukemia in blast crisis (CML-BC). Topics explored include the implication of PHF6 in various cellular functions, the chromosomal changes that contribute to the progression of CML to BC, and the analysis of the positive PHF6 mutations recorded following the genomic DNA sequencing performed.