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Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 1/29/2013, Vol. 110 Issue 5, p1821-1826, 6p
- Publication Year :
- 2013
-
Abstract
- The proportion of CD4 T cells with phenotypic and functional properties of naïve cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes. On treatment with a sphingosine-1-phosphate agonist, the frequency of these cells falls precipitously, but with a delay of ∼14 h compared with blood CD4 T cells; neither anti-CD62L nor pertussis toxin prevents entry of naïve CD4 T cells into the lung. Based on treatment with anti-CD62L and the use of CCR7<superscript>-/-</superscript> cells, lung naïve CD4 T cells appear to migrate to the mediastinal lymph nodes along a CD62L-independent, CCR7-dependent pathway. Cells that have entered the node in this manner are competent to respond to antigen. Thus, a portion (approximately one-half) of naïve CD4 T cells appears to enter the mediastinal lymph nodes through a blood-to-lung-to-lymph node route. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
LYMPH nodes
SPHINGOSINE
ANTIGENS
PERTUSSIS toxin
LUNGS
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 110
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 85432685
- Full Text :
- https://doi.org/10.1073/pnas.1221306110