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Granuloma cells in chronic inflammation express CD205 ( DEC205) antigen and harbor proliferating T lymphocytes: Similarity to antigen-presenting cells.
- Source :
- Pathology International; Feb2013, Vol. 63 Issue 2, p85-93, 9p, 4 Color Photographs, 1 Chart, 1 Graph
- Publication Year :
- 2013
-
Abstract
- Granulomas are classified as immune or foreign body granulomas. Of these, the immune granulomas, a hallmark of granulomatous inflammation, are closely related to cell-mediated immune responses. The aim of the present study is to characterize immune granuloma cells in 33 patients with granulomatous inflammation focusing on the expression of CD205 ( DEC205), a cell surface marker of antigen presenting cells, and their spatial relationship to T cells. CD205 was frequently expressed by immune granuloma cells, in contrast to foreign body granuloma cells that lacked CD205 expression. T cells were not only distributed in a lymphocyte collar around the granuloma, but also present among the granuloma cells (termed 'intra-granuloma T cells'). Intra-granuloma T cells stained positive for Ki-67 (median positivity = 9.4%) by double immunostaining for CD3 and Ki-67. This indicated the presence of proliferative stimuli within the granuloma that could activate the intra-granuloma T cells. The labeling index of Ki-67 in intra-granuloma T cells was significantly higher than that of T cells in the lymphocyte collar ( P < 0.0001) or T cells in the T cell zone (paracortex) of chronic tonsillitis or reactive lymphadenitis ( P = 0.002). These data indicate a close similarity between immune granulomas and antigen presenting cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13205463
- Volume :
- 63
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Pathology International
- Publication Type :
- Academic Journal
- Accession number :
- 85922711
- Full Text :
- https://doi.org/10.1111/pin.12036