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Intestinal DC in migrational imprinting of immune cells.
- Source :
- Immunology & Cell Biology; Mar2013, Vol. 91 Issue 3, p240-249, 10p, 3 Diagrams
- Publication Year :
- 2013
-
Abstract
- Dendritic cells (DCs) have a pivotal role in instructing antigen-specific immune responses, processing and presenting antigens to CD4<superscript>+</superscript> and CD8<superscript>+</superscript> T cells and producing factors capable to modulate the quality of T-cell responses. In this review, we will provide an historic overview on the identification of the mechanisms controlling lymphocyte migration into the largest immune organ of the body: the gut, and we will describe how in recent years an unexpected role for DCs has emerged as the architects in programming gut-homing immune cells. Specifically, we will review how intestinal DCs utilize the dietary vitamin A metabolite retinoic acid (RA) to program gut-homing lymphocytes and how intestinal DCs acquire the unique capacity to become RA producers. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNE response
ANTIGENS
T cells
LYMPHOCYTES
TRETINOIN
DENDRITIC cells
Subjects
Details
- Language :
- English
- ISSN :
- 08189641
- Volume :
- 91
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Immunology & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 85985056
- Full Text :
- https://doi.org/10.1038/icb.2012.73