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Total Synthesis of Chaetoquadrins H and I.
- Source :
- Synlett; 4/1/2013, Vol. 24 Issue 6, p723-726, 4p
- Publication Year :
- 2013
-
Abstract
- The first total syntheses of the chromone-containing natural products chaetoquadrins H and I are reported, using an aldol reaction and an acid-catalyzed deprotection/cyclization/elimination sequence. Chaetoquadrin H was isolated from the ascomycete Chaetomium quadrangulatum and exhibits potent mouse liver monoamine oxidase (MAO) inhibitory activity. Chaetoquadrin I was not isolated in sufficient quantity to enable biological evaluation. The synthesis of the title compounds provides a useful starting point for a medicinal chemistry program focused on chaetoquadrin natural products. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 24
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 86273443
- Full Text :
- https://doi.org/10.1055/s-0032-1318333