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Structural analysis of protein-protein interactions in type I polyketide synthases.
- Source :
- Critical Reviews in Biochemistry & Molecular Biology; Mar2013, Vol. 48 Issue 2, p98-122, 25p, 17 Diagrams
- Publication Year :
- 2013
-
Abstract
- Polyketide synthases (PKSs) are responsible for synthesizing a myriad of natural products with agricultural, medicinal relevance. The PKSs consist of multiple functional domains of which each can catalyze a specified chemical reaction leading to the synthesis of polyketides. Biochemical studies showed that protein-substrate and protein-protein interactions play crucial roles in these complex regio-/stereo-selective biochemical processes. Recent developments on X-ray crystallography and protein NMR techniques have allowed us to understand the biosynthetic mechanism of these enzymes from their structures. These structural studies have facilitated the elucidation of the sequence-function relationship of PKSs and will ultimately contribute to the prediction of product structure. This review will focus on the current knowledge of type I PKS structures and the protein-protein interactions in this system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10409238
- Volume :
- 48
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Critical Reviews in Biochemistry & Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- 86379737
- Full Text :
- https://doi.org/10.3109/10409238.2012.745476