The Influence of Pressure in Paracetamol Tablet Compaction on N Nuclear Quadrupole Resonance Signal.

N nuclear quadrupole resonance (N NQR) of several commercially available paracetamol tablets was measured. The spectra of two polymorphs are presented. The linewidths of the correspondent N NQR lines in all the measured samples containing the room-temperature stable monoclinic polymorph were noticeably different. We proved experimentally that the linewidth differences are the consequence of different compacting pressure in the production of tablets. [ABSTRACT FROM AUTHOR]