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Pulsed Dye Laser in the Treatment of Localized Scleroderma and Its Effects on CD34+ and Factor XIIIa+ Cells: An Immunohistochemical Study.
- Source :
- American Journal of Clinical Dermatology; 2013, Vol. 14 Issue 3, p235-241, 7p, 2 Color Photographs, 4 Charts
- Publication Year :
- 2013
-
Abstract
- Background: Localized scleroderma (morphea) is characterized by hardening and thickening of the dermis due to excessive collagen deposition. A decreased number of CD34+ cells and an increased number of Factor XIIIa+ cells are seen in the affected skin. The flashlamp pulsed dye laser (FLPDL) has been used in the treatment of localized morphea with promising results. Objective: The purpose of this study was to evaluate the therapeutic effectiveness of the pulsed dye laser in localized scleroderma and to assess its effect on CD34+ cells, Factor XIIIa+ cells, and blood vessels. Study Design: Thirty patients with plaque morphea were treated with a FLPDL (585 nm wavelength, 450 μs pulse duration). Fluence ranged from 7.5 to 8.5 J/cm. Sessions were performed biweekly for a maximum of 6 months. Clinical, histopathologic, and immunohistochemical assessments were performed. Results: Patients showed varying degrees of improvement of indurated skin. There was no worsening or further improvement at the treated sites during the follow-up assessments at 3, 6, and 12 months. An increased number of CD34+ cells were found in both the upper and the lower dermis, and a decreased number of Factor XIIIa+ cells were found in the lower dermis. Conclusion: The FLPDL is effective in the treatment of morphea, as confirmed by the changes in the pathologic tissue and levels of CD34+ and Factor XIIIa+ cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- SCLERODERMA (Disease) treatment
BLOOD coagulation factors
CHI-squared test
IMMUNOHISTOCHEMISTRY
MEDICAL lasers
HEALTH outcome assessment
SCLERODERMA (Disease)
STATISTICS
U-statistics
CD4 antigen
DATA analysis
RANDOMIZED controlled trials
TREATMENT effectiveness
DATA analysis software
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 11750561
- Volume :
- 14
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 87910073
- Full Text :
- https://doi.org/10.1007/s40257-013-0027-7