Methylation of KLF5 contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival.

The article presents a study on the effect of zinc finger transcription factor Krüppel-like factor 5 (KLF5) on acute myeloid leukaemia (AML). The study mentions that the KLF5 acts as a tumour suppressor showing growth inhibitory effects in tumours including prostate and oesophageal cancer. The study reveals that the hypermethylation of KLF5 leads to reduced expression of KLF5 in AML and is associated with reduced overall survival of patients within the intermediate cytogenetic risk group.