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Type 1 insulin-like growth factor receptor monoclonal antibody (HX-1162) treatment for liver cancer.
- Source :
- OncoTargets & Therapy; 2013, Vol. 6, p527-530, 4p
- Publication Year :
- 2013
-
Abstract
- One of the most important molecules mediating the proliferation, growth, and metastasis of cancer cells is insulin-like growth factor (IGF), with its receptor IGF-1R. Here, we describe the potential of an IGF-1R monoclonal antibody, HX-1162, on liver cancer apoptosis in vitro and in vivo. We found that HX-1162 could induce the apoptosis of cultured liver cancer cells. Additionally, HX-1162 treatment inhibited the tumor growth after cancer cell grafting and enhanced the cell apoptosis inside the tumor tissue. We conclude that IGF-1R targeting therapy provides a new avenue toward treating liver cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- INSULIN
PANCREATIC secretions
MONOCLONAL antibodies
CELLULAR pathology
Subjects
Details
- Language :
- English
- ISSN :
- 11786930
- Volume :
- 6
- Database :
- Complementary Index
- Journal :
- OncoTargets & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 88000368
- Full Text :
- https://doi.org/10.2147/OTT.S44162