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Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation.
- Source :
- Nature Immunology; Jun2001, Vol. 2 Issue 6, p542, 6p
- Publication Year :
- 2001
-
Abstract
- B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor Vav-2. However, the immune responses to type II thymus-independent antigen as well as the primary response to thymus-dependent (TD) antigen are defective. Vav-2?deficient mice are also defective in their ability to switch immunoglobulin class, form germinal centers and generate secondary immune responses to TD antigens. Mice lacking both Vav-1 and Vav-2 contain reduced numbers of B lymphocytes and display a maturational block in the development of mature B cells. B cells from Vav-1<superscript>-/-</superscript>Vav-2<superscript>-/-</superscript> mice respond poorly to antigen receptor triggering, both in terms of proliferation and calcium release. These studies show the importance of Vav-2 in humoral immune responses and B cell maturation. [ABSTRACT FROM AUTHOR]
- Subjects :
- CELLULAR signal transduction
IMMUNE response
B cells
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 2
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 8837416
- Full Text :
- https://doi.org/10.1038/88748