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Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization.
- Source :
- International Journal of Polymeric Materials & Polymeric Biomaterials; 2013, Vol. 62 Issue 14, p726-732, 7p, 1 Chart, 5 Graphs
- Publication Year :
- 2013
-
Abstract
- A series of biodegradable and pH/thermosensitive hydrogels based on monomethoxyl poly(ethylene glycol) (MPEG), poly(ϵ-caprolactone) (PCL), methylacrylic acid (MAA), and N-Isopropylacrylamide (NIPAAm) were prepared by UV-initiated free radical polymerization method. Swelling behavior and hydrolytic degradable behavior in aqueous medium with different pH values and pH/thermosensitivity of the hydrogels were studied in detail. The prepared biodegradable pH/thermo-sensitive hydrogels based on PCL, MPEG, MAA, and NIPAAm may have great potential application in smart drug delivery system. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00914037
- Volume :
- 62
- Issue :
- 14
- Database :
- Complementary Index
- Journal :
- International Journal of Polymeric Materials & Polymeric Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 88396084
- Full Text :
- https://doi.org/10.1080/00914037.2013.769233