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Dexamethasone induces apoptosis in human T cell clones expressing low levels of Bcl-2.
- Source :
- Cell Death & Differentiation; Jan1999, Vol. 6 Issue 1, p79, 8p
- Publication Year :
- 1999
-
Abstract
- Previous results of ours have demonstrated that the same clonotype can express both a sensitive and a resistant phenotype to Dex-mediated PCD induction depending on its cell cycle phase. In particular, we demonstrated that human T lymphocytes, arrested in the G0/G1 phase of the cell cycle, are susceptible, while proliferating T cells are resistant to Dexmediated apoptosis. In this paper, we have further characterized the sensitive and resistant phenotypes and investigated whether a different expression of the apoptotic genes Fas, FasL, Bcl-2, Bcl-x and Bax is involved in the regulation of Dexmediated apoptosis. The results show that the amount of Bcl-2 expression, that changes during cell cycle phases, determines susceptibility or resistance to apoptosis induced by Dex. In fact, undetectable expression of Bcl-2 in sensitive cells favors Dex-mediated apoptosis while high expression of Bcl-2 in proliferating cells counterbalances apoptosis induction. Moreover, the addition of exogenous IL-2, in the presence of Dex, fails to up-regulate Bcl-2 expression and to revert Dexmediated apoptotic phenomena. [ABSTRACT FROM AUTHOR]
- Subjects :
- APOPTOSIS
T cells
CELL cycle
Subjects
Details
- Language :
- English
- ISSN :
- 13509047
- Volume :
- 6
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Cell Death & Differentiation
- Publication Type :
- Academic Journal
- Accession number :
- 8851405
- Full Text :
- https://doi.org/10.1038/sj.cdd.4400461