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Identification of phenotypic markers of B cells from patients with Chagas disease.
- Source :
- Parasite Immunology; Jul/Aug2013, Vol. 35 Issue 7/8, p214-223, 10p
- Publication Year :
- 2013
-
Abstract
- Chagas disease was discovered more than a hundred years ago, but its pathogenesis is still not completely understood. Autoimmunity is one of the mechanisms shown to contribute to its pathogenesis, which may indicate an important participation of B lymphocytes. Patients with Chagas disease have shown increased percentage of B cells producing IL-10. However, there are no reports of the phenotypic markers of B cells producing IL-10 in patients with Chagas disease. For the first time in the literature, we evaluated the phenotypic profile of distinct markers of B cells from peripheral blood of noninfected individuals and patients with Chagas disease. Our results showed that patients with Chagas disease had a higher expression of CD21 and CD24 on the surface of CD19<superscript>+</superscript> B cells, while CD43 and CD23 were expressed equally in all groups. Moreover, the expression of MHC- II ( HLA- DR), CD80, CD86, caspase-3, granzyme B and intracellular IL-10 and TGF-β by CD19<superscript>+</superscript> B cells was higher in patients with Chagas disease. The results of IL-10 production within CD19<superscript>+</superscript> CD5<superscript>+</superscript> CD1d<superscript>+</superscript> B cells showed a higher percentage of this cytokine in patients with Chagas disease. Thus, our data bring a new knowledge about distinct markers of B cells in immune responses of Chagas disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHAGAS' disease
B cells
INTERLEUKIN-10
IMMUNE response
AUTOANTIBODIES
Subjects
Details
- Language :
- English
- ISSN :
- 01419838
- Volume :
- 35
- Issue :
- 7/8
- Database :
- Complementary Index
- Journal :
- Parasite Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 88800368
- Full Text :
- https://doi.org/10.1111/pim.12038