Maternal diet-induced obesity in swine with leptin resistance modifies puberty and pregnancy outputs of the adult offspring.

The assessment of reproductive features (puberty, fertility and prolificacy) in female Iberian pigs indicates that exposition to intrauterine maternal malnutrition, either by deficiency or excess, is associated with juvenile obesity and a significantly earlier age of puberty onset. At adulthood, prenatal exposition to undernutrition affects reproductive outputs by diminishing prolificacy, an effect that was not found in females exposed to prenatal overnutrition. [ABSTRACT FROM PUBLISHER]