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Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 7/2/2013, Vol. 110 Issue 27, p11103-11108, 6p
- Publication Year :
- 2013
-
Abstract
- Mobilization of the T-cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to harness antigen-presenting cells optimally to achieve an effective antitumor T-cell response. In this study, we show that anti-CD47 antibody-mediated phagocytosis of cancer by macrophages can initiate an antitumor T-cell immune response. Using the ovalbumin model antigen system, anti-CD47 antibody-mediated phagocytosis of cancer cells by macrophages resulted in increased priming of OT-IT cells [cluster of differentiation 8-positive (CD8<superscript>+</superscript>)] but decreased priming of OT-II T cells (CD4<superscript>+</superscript>. The CD4<superscript>+</superscript> T-cell response was characterized by a reduction in forkhead box P3-positive (Foxp3<superscript>+</superscript> regulatory T cells. Macrophages following anti-CD47-mediated phagocytosis primed CD8<superscript>+</superscript> I cells to exhibit cytotoxic function in vivo. This response protected animals from tumor challenge. We conclude that anti-CD47 antibody treatment not only enables macrophage phagocytosis of cancer but also can initiate an antitumor cytotoxic T-cell immune response. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHAGOCYTOSIS
IMMUNE response
T cells
MACROPHAGES
CANCER cell analysis
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 110
- Issue :
- 27
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 88923092
- Full Text :
- https://doi.org/10.1073/pnas.1305569110