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Cytotoxic activity of Pulsatilla chinensis saponins and their structure-activity relationship.
- Source :
- Journal of Asian Natural Products Research; May2013, Vol. 15 Issue 5, p680-686, 7p, 1 Diagram, 1 Chart
- Publication Year :
- 2013
-
Abstract
- The cytotoxic activity of 36 saponins isolated from roots of Pulsatilla chinensis (Bunge) Regel against the human cancer cell lines (A549, SGC-7901) and the human hepatic cell line (HL-7702) was tested by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay. Saponins 1-14 showed considerable cytotoxic activity, whereas saponins 15-36 showed no significant activity, which suggested that a free carboxylic group located at C-28 of aglycon is essential for their cytotoxic activity. Moreover, the analysis of structure-activity relationships also suggested that the oleanane-type saponins showed better cytotoxic activity than lupane-type saponins, and the length and linkage of glycotic chain attached to C-3 of aglycon displayed an important effect to the potent cytotoxicity. In conclusion, oleanolic acid 3-O-α-L- rhamnopyranosyl-(1 → 2)-[βD-glucopyranosyl-(1 → 4)]-β-L-arabinopyranoside (5) exhibited the most significant cytotoxic activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 15
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 89001046
- Full Text :
- https://doi.org/10.1080/10286020.2013.790901