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Effect of meal timing and glycaemic index on glucose control and insulin secretion in healthy volunteers.
- Source :
- British Journal of Nutrition; 10/14/2012, Vol. 108 Issue 7, p1286-1291, 6p
- Publication Year :
- 2012
-
Abstract
- Shiftworkers have a higher risk of CHD and type 2 diabetes. They consume a large proportion of their daily energy and carbohydrate intake in the late evening or night-time, a factor which could be linked to their increase in disease risk. We compared the metabolic effects of varying both dietary glycaemic index (GI) and the time at which most daily energy intake was consumed. We hypothesised that glucose control would be optimal with a low-GI diet, consumed predominantly early in the day. A total of six healthy lean volunteers consumed isoenergetic meals on four occasions, comprising either high- or low-GI foods, with 60% energy consumed predominantly early (breakfast) or late (supper). Interstitial glucose was measured continuously for 20 h. Insulin, TAG and non-esterified fatty acids were measured for 2 h following every meal. Highest glucose values were observed when large 5021 kj (1200 kcal) high-GI suppers were consumed. Glucose levels were also significantly higher in predominantly late high- v. low-GI meals (P<0.00. Using an estimate of postprandial insulin sensitivity throughout the day, we demonstrate that this follows the same trend, with insulin sensitivity being significantly worse in high energy consumed in the evening meal pattern. Both meal timing and GI affected glucose tolerance and insulin secretion. Avoidance of large, high-GI meals in the evening may be particularly beneficial in improving postprandial glucose profiles and may play a role in reducing the risk of type 2 diabetes; however, longer-term studies are needed to confirm this. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYPERGLYCEMIA prevention
HYPOGLYCEMIA
TYPE 2 diabetes prevention
GLUCOSE metabolism
ANALYSIS of variance
BLOOD sugar
BLOOD sugar monitoring
FATTY acids
GLYCEMIC index
INGESTION
INSULIN
INSULIN resistance
LONGITUDINAL method
PATIENT monitoring
RESEARCH funding
STATISTICS
TIME
TRIGLYCERIDES
DATA analysis
REPEATED measures design
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 00071145
- Volume :
- 108
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- British Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 89465678
- Full Text :
- https://doi.org/10.1017/S0007114511006507