The Morphological Aspects of Neovaginoplasty Using Oxidized Cellulose Membrane (Interceed®).

Objective: The purpose of this study was to evaluate the postoperative morphologic aspects of neovaginoplasty by the McIndoe technique with the use of an oxidized cellulose membrane (Interceed^®) - an absorbable adhesion barrier - to correct congenital vaginal defects. Design: This study was designed as a prospective study. Patients and Methods: The sample consisted of 10 patients treated at the Department of Urogynecology, Federal University of São Paulo, 7 patients with Mayer-Rokitansky-Küster-Hauser Syndrome, and 3 patients with congenital vaginal atresia. In order to evaluate the epithelization process, monthly biopsies for the first 3 months and then on the 9th month after neovaginoplasty using Interceed, were collected. Results: In all patients, lamina propria rich in blood vessels and epithelioid cells were found in a vaginal fragment after 1 month of the neovaginoplasty. Typical vaginal epithelium was also observed and the reaction for identification of glycogen (PAS) was positive 9 months after surgery in all cases. Conclusions: The oxidized cellulose membrane proved to be a suitable material to use as coating of the neovagina for the correction of congenital defects such as vaginal agenesis. It is possible to obtain a typical vaginal epithelium after the use of this absorbable adhesion barrier. (J GYNECOL SURG 29:169) [ABSTRACT FROM AUTHOR]