Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination.

Authors :: Aarntzen, Erik H. J. G.
Srinivas, Mangala
Schreibelt, Gerty
Heerschap, Arend
Punt, Cornelius J. A.
Figdor, Carl G.
Oyen, Wim J.
De Vries, I Jolanda M.
Source :: OncoImmunology; Jul2013, Vol. 2 Issue 7, pe24661-1-e24661-2, 2p
Publication Year :: 2013
Abstract: Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting. [ABSTRACT FROM AUTHOR]

Subjects :: DENDRITIC cells
LYMPH nodes
INTRADERMAL injections
VACCINATION
VACCINES

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