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Characterization of hepatitis B virus genotypes and quantitative hepatitis B surface antigen titres in North American tertiary referral liver centres.
- Source :
- Liver International; Oct2013, Vol. 33 Issue 9, p1363-1369, 7p, 1 Chart, 1 Graph, 1 Map
- Publication Year :
- 2013
-
Abstract
- Background & Aims Hepatitis B virus ( HBV) genotype and quantitative hepatitis B surface antigen ( qHBsAg) have been related to clinical outcome. In this nationwide cross-sectional study, we aimed to investigate the epidemiology and clinical significance of HBV genotype and qHBsAg in patients with chronic hepatitis B ( CHB). Methods Six hundred and thirty patients with CHB were seen in four urban tertiary referral centres in Canada. HBV genotype was determined by line probe assay (INNO-LIPA) and HBV DNA quantified by commercial PCR (Roche TaqMan, sensitivity <55 IU/ml or AMPLICOR, sensitivity <60 IU/ml). Titres of qHBsAg were determined by an in-house assay based on the WHO standard (calibration range 0.24-62.5 IU/ml). Results In 630 patients (57% male, 69% Asian, median age 42 years), 21% were hepatitis B e antigen positive and the median alanine aminotransferase was 29 U/L. The HBV genotype distribution was A (16%), B (29%), C (31%), D (16%), E (6%). HBV genotype was strongly associated with ethnicity, but neither genotype nor qHBsAg correlated with the degree of fibrosis. In the treatment-naïve patients, the baseline qHBsAg levels correlated with HBV DNA ( r = 0.2517, P < 0.0008). The median qHBsAg levels were lowest in patients with genotype B ( P < 0.0001), but no significant correlation was noted with all other HBV genotypes. Conclusions In this large North American HBV epidemiological study, genotypes B and C were the most common; however, all genotypes (A-E) were observed with varied distribution nationwide. Baseline qHBsAg significantly correlated with HBV DNA and with HBV genotype B, but not with liver fibrosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14783223
- Volume :
- 33
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Liver International
- Publication Type :
- Academic Journal
- Accession number :
- 90133197
- Full Text :
- https://doi.org/10.1111/liv.12222