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Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia.
- Source :
- Journal of Enzyme Inhibition & Medicinal Chemistry; Oct2013, Vol. 28 Issue 5, p997-1001, 5p
- Publication Year :
- 2013
-
Abstract
- A new cinnamic acid derivative was isolated from the whole plant of Viola betonicifolia as off white needle. On the basis of various modern spectroscopic techniques including HREI-MS and 1D and 2D NMR, its structure was elucidated as 2,4-dihydroxy, 5-methoxy-cinnamic acid. It showed marked inhibition against DPPH (diphenyl-2-picryl hydrazyl) free radicals with IC<subscript>50</subscript> = 124 ± 5.76 µM. The antioxidant property of the compound was compared with α-tocopherole and vitamin C having IC<subscript>50</subscript> values 96 ± 0.46 and 90 ± 0.56 µM, respectively. In case of antiglycation assay, the compound exhibited moderate activity (IC<subscript>50</subscript> = 355 ± 7.56 µM) similar to standard compound, rutin (IC<subscript>50</subscript> = 294 ± 0.56 µM). However, it was non-toxic to PC-3 cell line. It is concluded that 2,4-dihydroxy, 5-methoxy-cinnamic acid has antiglycation potential which was further augmented by its antioxidant activity and thus offered an ideal natural therapeutic option for the effective management of diabetes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14756366
- Volume :
- 28
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Enzyme Inhibition & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 90165321
- Full Text :
- https://doi.org/10.3109/14756366.2012.702344