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Delayed Elimination of Digoxin Antidotum Determined by Radioimmunoassay.
- Source :
- Journal of Clinical Pharmacology; Jan1989, Vol. 29 Issue 1, p41-45, 5p
- Publication Year :
- 1989
-
Abstract
- An observation of a treatment with digitalis antibodies (Fab-fragments) in a young child is presented. The elimination of this antidotum proved to be much slower than normally expected. In the patient's history, the disappearance of the Fab-fragments out of the blood lasted 142 days with a half-life of 15.6 days, whereas an elimination with a T<subscript>½</subscript> of 28 hours is accepted. Probably there has been intracellular penetration of the antibodies into the liver, caused by concomitant diseases (Hepatitis A and B infections). An 'in vitro' experiment is reported. It demonstrates the equimolar binding of the Fab-fragments for digoxin and shows that the elimination of the Fab-fragments can be established by a routine radioimmunoassay of digoxin, in an indirect way. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00912700
- Volume :
- 29
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 90344990
- Full Text :
- https://doi.org/10.1002/j.1552-4604.1989.tb03235.x