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Renin Inhibition: A New Approach to Cardiovascular Therapy.

Authors :
Frishman, William H.
Fozailoff, Alan
Lin, Cherry
Dike, Chidiadi
Source :
Journal of Clinical Pharmacology; Sep1994, Vol. 34 Issue 9, p873-880, 8p
Publication Year :
1994

Abstract

The renin-angiotensin system (RAS) functions as a primary regulator in the short-term and long-term control of blood pressure. Pharmacologic inhibition of the RAS with angiotensin-converting enzyme (ACE) inhibition is effective for treating systemic hypertension and congestive heart failure. As a more specific therapy, the development of renin inhibitors has evolved through various approaches: specific renin antibodies, peptides developed from prosegments of renin precursor, oligopeptides related to pepstatin a universal inhibitor of aspartyl proteinase enzyme, and analogs of angiotensinogen (the renin substrate). Angiotensinogen analogs are promising as therapeutic agents because of high potency, metabolic stability, and good oral bioavailability. Ongoing research is directed towards the application of renin inhibition, the treatment of various cardiovascular disorders, and as a biological probe for understanding the role of the RAS in control of blood pressure and blood volume. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00912700
Volume :
34
Issue :
9
Database :
Complementary Index
Journal :
Journal of Clinical Pharmacology
Publication Type :
Academic Journal
Accession number :
90346035
Full Text :
https://doi.org/10.1002/j.1552-4604.1994.tb04000.x