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Gray Matter Is Targeted in First-Attack Multiple Sclerosis.

Authors :
Schutzer, Steven E.
Angel, Thomas E.
Liu, Tao
Schepmoes, Athena A.
Xie, Fang
Bergquist, Jonas
Vécsei, László
Zadori, Denes
Camp II, David G.
Holland, Bart K.
Smith, Richard D.
Coyle, Patricia K.
Source :
PLoS ONE; Sep2013, Vol. 8 Issue 9, p1-7, 7p
Publication Year :
2013

Abstract

The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain unknown. Some imaging studies suggest gray rather than white matter may be involved early, and some postulate this may be predictive of developing MS. Other imaging studies are in conflict. To determine if there was objective molecular evidence of gray matter involvement in early MS we used high-resolution mass spectrometry to identify proteins in the cerebrospinal fluid (CSF) of first-attack MS patients (two independent groups) compared to established relapsing remitting (RR) MS and controls. We found that the CSF proteins in first-attack patients were differentially enriched for gray matter components (axon, neuron, synapse). Myelin components did not distinguish these groups. The results support that gray matter dysfunction is involved early in MS, and also may be integral for the initial clinical presentation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
8
Issue :
9
Database :
Complementary Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
90530355
Full Text :
https://doi.org/10.1371/journal.pone.0066117