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The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
- Source :
- British Journal of Clinical Pharmacology; 1980, Vol. 9 Issue 2, p137-143, 7p
- Publication Year :
- 1980
-
Abstract
- 1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2- thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03065251
- Volume :
- 9
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- British Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 90923232
- Full Text :
- https://doi.org/10.1111/j.1365-2125.1980.tb05823.x