Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives from Trisubstituted α-Aminophosphonates.

An efficient method for the preparation of quaternary α-aminophosphonic acid derivatives is reported. The nucleophilic addition of organometallic reagents to α-ketiminophosphonates allows the preparation of quaternary α-aminophosphonates. The diastereoselective synthesis of a quaternary α-aminophosphonate using a chiral tartaric-acid-derived phosphonate is also described. [ABSTRACT FROM AUTHOR]