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Antigen presentation by parenchymal cells: a route to peripheral tolerance?
- Source :
- Immunological Reviews; Dec99, Vol. 172 Issue 1, p297-314, 18p
- Publication Year :
- 1999
-
Abstract
- T-cell activation and the development of efficient immune responses requires the delivery, by the antigen-presenting cell, of two distinct signals. The first results from the engagement of the TCR:CD3:CD4 complex, and the second from the interaction of CD28 with the B7 family of co-stimulatory molecules. In this context, the physiological significance and the functional consequences of antigen presentation by B7-deficient parenchymal cells, which express MHC class II molecules as a result of inflammation, remains a matter of debate. In this paper we have attempted to critically review the often conflicting reports on the functional effects of antigen presentation by epithelial and endothelial cells to T cells, both in vitro and in vivo. Our own findings are summarised in a model which is consistent with the suggestion of an important role for antigen presentation by parenchymal cells in the induction and the maintenance of peripheral tolerance. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIGENS
T cells
IMMUNE response
MAJOR histocompatibility complex
Subjects
Details
- Language :
- English
- ISSN :
- 01052896
- Volume :
- 172
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Immunological Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 9181458
- Full Text :
- https://doi.org/10.1111/j.1600-065X.1999.tb01374.x