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Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease.
- Source :
- Inflammation; Dec2013, Vol. 36 Issue 6, p1225-1231, 7p
- Publication Year :
- 2013
-
Abstract
- Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 −330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 −330GG genotype was significantly increased in CAD than in controls ( p = 5.1 × 10). Function analysis revealed that subjects carrying IL-2 −330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes ( p < 0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls ( p < 0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected ( p < 0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03603997
- Volume :
- 36
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 91842210
- Full Text :
- https://doi.org/10.1007/s10753-013-9659-2