Synthesis of 4-Arylquinazolines by Arylation of Quinazolin-4-ones under Mild Conditions.

An efficient route to 4-arylquinazolines via arylation of quinazolin-4-ones under mild condition is described. The reaction is carried out by the palladium-catalyzed coupling of quinazolin-4- ones with arylboronic acids in the presence of TsCl leading to 4-arylquinazolines in good to excellent yields. [ABSTRACT FROM AUTHOR]