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Abnormality of regulatory T-cells in remission and non-remission idiopathic thrombocytopaenic purpura patients.
- Source :
- Platelets; Dec2013, Vol. 24 Issue 8, p625-631, 7p
- Publication Year :
- 2013
-
Abstract
- Primer immunologic defect in patients with idiopathic thrombocytopaenic purpura (ITP) result from autoreactive B-lymphocytes secreting antiplatelet antibodies. Dysfunctional cellular immunity has also great importance in ITP pathogenesis. CD4<superscript>+</superscript>CD25<superscript>+</superscript> regulatory T-cells hav immunoregulatory features and it is able to inhibit CD4<superscript>+</superscript>CD25<superscript>-</superscript> and CD8<superscript>+</superscript> responses. ITP is also an autoimmune disease; the CD4<superscript>+</superscript>CD25<superscript>+</superscript> T-cell levels of the patients decrease during the active state. According to our findings, immunosuppressive treatments increase the CD4<superscript>+</superscript>CD25<superscript>+</superscript> Treg cell levels in the non-remission ITP patients. However, this level is not enough to overcome the resistance. CD4<superscript>+</superscript>CD25<superscript>-</superscript>Foxp3<superscript>+</superscript> and CD4<superscript>+</superscript>Foxp3<superscript>+</superscript> Treg cells are responsible for the pathogenesis of the non-remission ITP patients and other factors exist, which are responsible for the resistance of ITP treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09537104
- Volume :
- 24
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Platelets
- Publication Type :
- Academic Journal
- Accession number :
- 91924975
- Full Text :
- https://doi.org/10.3109/09537104.2012.748188