Abnormality of regulatory T-cells in remission and non-remission idiopathic thrombocytopaenic purpura patients.

Primer immunologic defect in patients with idiopathic thrombocytopaenic purpura (ITP) result from autoreactive B-lymphocytes secreting antiplatelet antibodies. Dysfunctional cellular immunity has also great importance in ITP pathogenesis. CD4⁺CD25⁺ regulatory T-cells hav immunoregulatory features and it is able to inhibit CD4⁺CD25^- and CD8⁺ responses. ITP is also an autoimmune disease; the CD4⁺CD25⁺ T-cell levels of the patients decrease during the active state. According to our findings, immunosuppressive treatments increase the CD4⁺CD25⁺ Treg cell levels in the non-remission ITP patients. However, this level is not enough to overcome the resistance. CD4⁺CD25^-Foxp3⁺ and CD4⁺Foxp3⁺ Treg cells are responsible for the pathogenesis of the non-remission ITP patients and other factors exist, which are responsible for the resistance of ITP treatment. [ABSTRACT FROM AUTHOR]