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Insulin-like growth factor 1 opposes the effects of C-reactive protein on endothelial cell activation.
- Source :
- Molecular & Cellular Biochemistry; Jan2014, Vol. 385 Issue 1/2, p199-205, 7p
- Publication Year :
- 2014
-
Abstract
- Emerging evidence demonstrates that high plasma C-reactive protein (CRP) levels or low plasma insulin-like growth factor 1 (IGF-1) concentrations may be separately associated with the increased risk of coronary artery disease or myocardial infarction. Interestingly, animal model studies and epidemiological investigations indicate that circulating IGF-1 and CRP levels have an inverse correlation. The present study aims to evaluate if IGF-1 can directly oppose the effects of CRP on endothelial cell (EC) activation. We found that IGF-1 rescues endothelial nitric oxide synthase activity and decreases the release of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 from ECs. We also showed that IGF-1 antagonizes the effects of CRP by activating the PI3K/Akt pathway and suppressing the JNK/c-Jun and MAPK p38/ATF2 signaling pathways, rather than inhibiting ERK1/2 activity. These findings provide evidence of the physiopathological mechanisms of endothelial activation and novel insights into the protective properties of IGF-1. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03008177
- Volume :
- 385
- Issue :
- 1/2
- Database :
- Complementary Index
- Journal :
- Molecular & Cellular Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 92577018
- Full Text :
- https://doi.org/10.1007/s11010-013-1828-y