Serum Interleukin-18 Levels Are Associated with Physical Activity in Japanese Men.

Objective: To investigate the link between serum interleukin-18 (IL-18) levels and physical activity in Japanese men. Methods: A total of 81 men (45.7±17.6 years old) was enrolled in this cross-sectional investigation study. We assessed anthropometric and body composition parameters. Serum IL-18 levels, physical activity by uniaxial accelerometers, peak oxygen uptake and metabolic risk parameters were also evaluated. Results: Serum IL-18 levels were 179.4±84.7 pg/mL. Physical activity evaluated by Σ[metabolic equivalents × h per week (METs⋅h/w)]was significantly and negatively correlated with serum IL-18 levels (r = −0.252, p = 0.0235). These associations remained even after adjusting for age, peak oxygen uptake and other confounding factors. Conclusion: Serum IL-18 levels were closely associated with physical activity independent of peak oxygen uptake in Japanese men. [ABSTRACT FROM AUTHOR]