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Higher CD27+CD8+ T Cells Percentages during Suppressive Antiretroviral Therapy Predict Greater Subsequent CD4+ T Cell Recovery in Treated HIV Infection.
- Source :
- PLoS ONE; Dec2013, Vol. 8 Issue 12, p1-6, 6p
- Publication Year :
- 2013
-
Abstract
- HIV-mediated immune dysfunction may influence CD4<superscript>+</superscript> T cell recovery during suppressive antiretroviral therapy (ART). We analyzed cellular biomarkers of immunological inflammation, maturation, and senescence in HIV-infected subjects on early suppressive ART. We performed longitudinal analyses of peripheral immunological biomarkers of subjects on suppressive ART (n = 24) from early treatment (median 6.4 months, interquartile range [IQR] 4.8–13.9 months) to 1–2 years of follow-up (median 19.8 months, IQR 18.3–24.6 months). We performed multivariate regression to determine which biomarkers were associated with and/or predictive of CD4<superscript>+</superscript> T cell recovery. After adjusting for the pre-ART CD4<superscript>+</superscript> T cell count, age, proximal CD4<superscript>+</superscript> T cell count, and length of ART medication, the percentage of CD27<superscript>+</superscript>CD8<superscript>+</superscript> T cells remained significantly associated with the CD4<superscript>+</superscript> T cell recovery rate (β = 0.092 cells/ul/month, P = 0.028). In HIV-infected subjects starting suppressive ART, patients with the highest percentage of CD8<superscript>+</superscript> T cells expressing CD27 had the greatest rate of CD4<superscript>+</superscript> T cell recovery. [ABSTRACT FROM AUTHOR]
- Subjects :
- CD27 antigen
ANTIRETROVIRAL agents
CD8 antigen
CD4 antigen
T cells
HIV infections
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 93397880
- Full Text :
- https://doi.org/10.1371/journal.pone.0084091