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HIV integration and T cell death: additional commentary.

Authors :
Cooper, Arik
García, Mayra
Petrovas, Constantinos
Takuya Yamamoto
Koup, Richard A.
Nabel, Gary J.
Source :
Retrovirology; 2013, Vol. 10 Issue 1, preceding p1-6, 7p
Publication Year :
2013

Abstract

Estaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death signaling, leading to p53 phosphorylation and cell demise (Cooper A et al. Nature 498:376-379, 2013). They have raised several hypothetical points that we further clarify here. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17424690
Volume :
10
Issue :
1
Database :
Complementary Index
Journal :
Retrovirology
Publication Type :
Academic Journal
Accession number :
93597623
Full Text :
https://doi.org/10.1186/1742-4690-10-150