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Efficient Prevention Strategy against the Development of a Palmar-Plantar Erythrodysesthesia during Chemotherapy.
- Source :
- Skin Pharmacology & Physiology; Jan2014, Vol. 27 Issue 2, p66-70, 5p
- Publication Year :
- 2014
-
Abstract
- Background: Pegylated liposomal doxorubicin (PLD) is a highly efficient chemotherapeutic; however, it induces dermal side effects such as palmar-plantar erythrodysesthesia (PPE) in up to 80% of cases, probably by being emitted with the sweat onto the skin surface. Aim: The aim of the present study was to examine whether a topically applied ointment containing antioxidants with a high radical protection factor is able to prevent the formation of PPE. Methods: Twenty patients suffering from ovarian carcinoma and treated with PLD were observed. Results: 60% of the patients tolerated the regular application of the cream and developed no PPE. The remaining 40% interrupted the application. Six of them developed PPE and resumed ointment application thereafter. In these cases the PPE disappeared or was strongly reduced. Conclusion: The results of the observation clearly demonstrate that topical application of the ointment is an efficient strategy against the development of PPE during chemotherapy with PLD. Copyright © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- DOXORUBICIN
OVARIAN cancer
CANCER chemotherapy
ANTIOXIDANTS
PERSPIRATION
Subjects
Details
- Language :
- English
- ISSN :
- 16605527
- Volume :
- 27
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Skin Pharmacology & Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 93707266
- Full Text :
- https://doi.org/10.1159/000351801